The report explores global and regional trends and innovations that are transforming the tourism sector, with an emphasis on ICT-based innovations. Given the challenges of the Caribbean’s tourism industry, the report underlines the need for approaching future tourism development with a high innovation scope in order to be and remain competitive in the global economy. The report suggests an innovation framework for regions where SMEs need to be empowered through the adoption of technologies when facing international competition. The prior is boosted by a framework of an adequate clustering and co-working policy atmosphere created by public policies. The document closes with some conclusions and a set of guidelines for the Caribbean Region.